CJC-1295 DAC (20mg)
Original price was: $110.00.$62.00Current price is: $62.00.
CJC-1295 is a synthetic analogue of growth hormone releasing hormone (GHRH) that increases plasma levels of growth hormone and insulin-like growth factor 1 (IGF-1). DAC is an additive moiety that prolongs the plasma half-life of CJC-1295.
Contents of the Package
- 1 sterile 10ml multi-dose vial
- Active ingredient: CJC-1295 with DAC at 2mg/ml
- Diluted in sterile bacteriostatic saline
- Clear, injectable solution
- Packaged in pharmaceutical-grade glass vial with tamper-evident seal
- For subcutaneous administration only
About CJC-1295 DAC
CJC-1295 with DAC (Drug Affinity Complex) is a long-acting analog of Growth Hormone Releasing Hormone (GHRH 1-29), engineered for sustained stimulation of endogenous growth hormone (GH) and insulin-like growth factor-1 (IGF-1) release. The inclusion of DAC significantly extends its half-life from minutes (as seen in native GHRH) to up to 8–10 days, allowing for less frequent dosing and more stable GH pulsatility.
CJC-1295 is often used to support:
- Anti-aging and vitality protocols
- Muscle recovery and lean mass development
- Fat metabolism and body recomposition
- Sleep quality, cognition, and skin health
Its unique structure enhances binding to albumin, reducing renal clearance and enabling prolonged biological activity.
Mechanism of Action
CJC-1295 functions as a GHRH analog, binding to GHRH receptors in the anterior pituitary to stimulate endogenous growth hormone release. The addition of DAC extends its biological half-life by promoting covalent binding to albumin and reducing proteolytic degradation.
Key physiological actions include:
- Increased amplitude and frequency of GH pulses
- Subsequent elevation of circulating IGF-1 levels
- Stimulation of protein synthesis and lipolysis
- Promotion of lean muscle gain and fat metabolism
- Improved cellular repair and collagen production
CJC-1295 with DAC does not inhibit the normal negative feedback mechanisms of GH secretion, preserving natural pulsatility while amplifying its effect.
Adverse Reactions
CJC-1295 with DAC is generally well tolerated, with most side effects being mild and transient.
Reported side effects may include:
- Mild water retention or bloating
- Temporary numbness or tingling (paresthesia)
- Fatigue or lightheadedness
- Headache or flushing
- Mild injection site irritation
Higher doses may lead to increased hunger or minor joint discomfort due to elevated IGF-1 levels.
Benefits
Potential Benefits:
- Enhanced muscle growth and recovery
- Improved fat metabolism and body composition
- Better sleep quality via increased GH output during deep sleep
- Increased skin elasticity and collagen repair
- Support for joint and connective tissue recovery
May improve cognitive clarity and mood
Side Effects
⚠️ Possible Side Effects:
- Water retention or slight weight fluctuation
- Numbness or tingling (especially in hands or feet)
- Headaches or flushing after injection
- Rare: increased hunger or slight insulin resistance with long-term high doses
Contraindications & Precautions
- Hypersensitivity to peptide-based medications
- Use with caution in individuals with active malignancies, as elevated GH/IGF-1 may potentially stimulate tumor growth
- Not recommended for individuals with uncontrolled diabetes, acromegaly, or pituitary adenomas
- Monitor IGF-1 levels and fasting glucose during prolonged use
- Avoid use with concurrent GH therapy unless medically directed
Drug Interactions
- May have additive effects with GH secretagogues such as Ipamorelin or MK-677
- No direct drug-drug interactions reported
- Avoid concurrent use with exogenous GH unless under physician supervision due to possible feedback suppression
Pregnancy & Breastfeeding
There is no clinical safety data available for the use of CJC-1295 in pregnant or breastfeeding individuals. Due to the growth-promoting and hormonal effects of the compound, it is not recommended during pregnancy or lactation.
Children
CJC-1295 is not approved for pediatric use. While it mimics natural GHRH and may theoretically benefit growth hormone-deficient children, it should only be considered under strict endocrinological supervision in such cases. Unsupervised use in children is contraindicated.
FDA approval
CJC-1295 (with or without DAC) is not FDA-approved as a therapeutic drug. It remains under clinical investigation and is available through compounding pharmacies and research outlets. It is not approved as a treatment for GH deficiency or related conditions.
References
- Teichman SL, et al. (2006). "Pharmacokinetics of CJC-1295, a long-acting GHRH analog." Journal of Clinical Endocrinology & Metabolism.
- Ip C, et al. (2009). "GH and IGF-1 responses to CJC-1295 with DAC." Clinical Pharmacology & Therapeutics.
- Meinhardt U, et al. (2010). "Long-acting GHRH analogs in metabolic health." Hormone Research in Paediatrics.
- Bartke A. (2011). "The role of GH in aging and longevity." Endocrine Reviews.
- Liu NA, et al. (2021). "Clinical applications and risks of GHRH analogs." Trends in Endocrinology & Metabolism.