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NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme in all living cells, essential for metabolic processes and cellular function. It acts as a mediator of redox reactions, alternating between its oxidized (NAD+) and reduced (NADH) forms to facilitate electron transfer, crucial for energy production and sustaining life. Involved in over 500 enzymatic reactions, NAD+ is central to maintaining cellular homeostasis. Research shows that NAD+ may be beneficial in improving muscle function, protecting cells of the nervous system, and generally reducing the effects of aging.
Beyond energy metabolism, NAD+ supports DNA repair and gene regulation through enzymes like sirtuins and PARPs. Sirtuins use NAD+ to regulate cellular functions such as DNA repair, gene expression, and aging, while PARPs utilize it to repair DNA damage and maintain genomic stability. These roles underscore NAD+’s importance in cellular integrity and combating aging.
NAD⁺ injections are typically administered intramuscularly, with dosing adjusted based on individual goals such as cellular energy support, neuroprotection, detoxification, or anti-aging.
A common starting dose is 100 mg (1 ml) administered 1–3 times per week. For therapeutic or intensive protocols, doses may be titrated gradually to 200–300 mg (2–3 ml) per session, administered up to 2–3 times weekly.
A standard escalation schedule may follow this approach:
Week 1: 100 mg (1 ml) IM, twice weekly
Week 2–3: Increase to 200 mg (2 ml) IM, two to three times weekly
Week 4 and beyond: Maintain at 200–300 mg (2–3 ml) per injection, based on tolerance and desired outcome
Injections are administered intramuscularly in large muscles (gluteus or deltoid), and should be injected slowly to reduce discomfort. Some users may experience a warming sensation, muscle ache, or mild fatigue post-injection, which typically resolves within a few hours.
NAD⁺ is a vital coenzyme found in all living cells, playing a central role in mitochondrial function, energy metabolism, DNA repair, and cellular signaling. It is an essential molecule in redox reactions, particularly in converting nutrients into cellular energy (ATP) via the Krebs cycle and oxidative phosphorylation.
NAD⁺ levels naturally decline with age, stress, toxin exposure, and chronic illness — contributing to mitochondrial dysfunction, fatigue, cognitive decline, and metabolic syndromes. Intramuscular NAD⁺ supplementation may help restore these levels, promoting systemic vitality and neuroprotection.
NAD⁺ functions as a critical redox coenzyme, alternating between NAD⁺ and NADH to shuttle electrons during cellular respiration. It is essential for ATP production, cellular repair, and signaling.
Key pathways affected by NAD⁺ include:
Mitochondrial function: Boosts oxidative phosphorylation and cellular energy
Sirtuin activation: Supports anti-aging gene expression and DNA repair
PARP activity: Promotes DNA damage response and genomic stability
Neurotransmitter synthesis: Assists in dopamine, serotonin, and noradrenaline metabolism
Detoxification: Assists liver in converting reactive oxygen species and toxins
By replenishing NAD⁺ levels, the body may restore metabolic efficiency, immune balance, and neurological resilience.
There is limited human safety data on NAD⁺ injections in pregnant or breastfeeding individuals. While NAD⁺ is a naturally occurring molecule, use during pregnancy or lactation is not currently recommended due to lack of conclusive data.
NAD⁺ injections are not approved for pediatric use. While NAD⁺ is vital to metabolism in all age groups, supplementation should be reserved for adults unless prescribed by a pediatric specialist under clinical supervision.
NAD⁺ is not FDA-approved as a pharmaceutical drug for injectable use. It is available through compounding pharmacies and used in clinical wellness, addiction recovery, anti-aging, and functional medicine practices. FDA-approved uses of NAD precursors (e.g., niacinamide) exist, but injectable NAD⁺ is considered investigational.
